Clinical Isolates of Antimicrobial-Resistant Enterobacter Species Can Persist in Human Macrophages Without Replication and Overt Cellular Cytotoxicity
Enterobacter spp clinical isolates can persist without replication inside human macrophages with minimal effects on cell integrity and inflammation. These observations could have implications for clinical outcome of patients that cannot readily clear Enterobacter infections, which can potentially lead to prolonged intracellular survival and infection relapse.
Authors
- Helina Marshall (ORCID: https://orcid.org/0000-0001-5054-7301)
- Michael C. Gilmore (ORCID: https://orcid.org/0000-0002-6848-5134)
- Miguel A. Valvano (ORCID: https://orcid.org/0000-0001-8229-3641)
- Hannah Parks
- Fabiana Bisaro (ORCID: https://orcid.org/0009-0009-7848-8847)
- Georgiana Parau
- Inmaculada García‐Romero (ORCID: https://orcid.org/0000-0002-8939-3271)
- Samuel O. Korankye
- Amy J. G. Anderson (ORCID: https://orcid.org/0009-0004-7735-2220)
Institutions
- Queen's University Belfast (GB)
- University of Strathclyde (GB)
- Centro Andaluz de Biología del Desarrollo (ES)
- Universidad Pablo de Olavide (ES)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1093/infdis/jiaf099
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Department for the Economy
- International Association for the Exchange of Students for Technical Experience
- Biotechnology and Biological Sciences Research Council