Effects of Amikacin Liposome Inhalation Suspension and Amikacin Resistance Development in Patients With Refractory <i>Mycobacterium avium</i> Complex Pulmonary Disease
Regimens that included ALIS achieved higher culture conversion in NC-NB than cavitary MAC-PD cases. High CRP levels, cavitary disease, and CLM resistance predicted persistent culture positivity. AMK resistance acquired during ALIS administration may limit treatment options for refractory MAC-PD.
Authors
- Takehiko Kobayashi (ORCID: https://orcid.org/0000-0003-2085-4292)
- Toshiharu Mitsuhashi (ORCID: https://orcid.org/0000-0001-9940-0570)
- Satoshi Mitarai (ORCID: https://orcid.org/0000-0002-2288-077X)
- Yohei Kawasaki (ORCID: https://orcid.org/0000-0002-7474-7647)
- Yuya Tanaka (ORCID: https://orcid.org/0000-0002-5844-1904)
- Shiomi Yoshida (ORCID: https://orcid.org/0000-0002-8197-3829)
- Yu Kurahara (ORCID: https://orcid.org/0000-0002-3606-0975)
- Asami Osugi (ORCID: https://orcid.org/0000-0002-1354-6040)
- Kazunari Tsuyuguchi (ORCID: https://orcid.org/0000-0002-3918-1764)
Institutions
- Japan Anti Tuberculosis Association (JP)
- Okayama University Hospital (JP)
- NHO Kinki Chuo Chest Medical Center (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1093/ofid/ofaf118
- Citations
- 4
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 5.42