Arrestin domain containing 3 promotes alcohol-induced liver steatosis by reducing stearoyl-CoA desaturase-1 ubiquitinated degradation
Our findings reveal that ARRDC3 promotes hepatic steatosis in ALD by reducing the ubiquitin-dependent degradation of SCD1. ARRDC3 may serve as a potential therapeutic target for ALD.
Authors
- Zhenwei Zhong
- Haoxiong Zhou (ORCID: https://orcid.org/0000-0002-3781-5241)
- Xuemei Pan (ORCID: https://orcid.org/0000-0003-0533-3739)
- Yin Tang (ORCID: https://orcid.org/0009-0006-6130-3509)
- Yunwei Guo (ORCID: https://orcid.org/0000-0003-1008-3228)
- Huiling Liu (ORCID: https://orcid.org/0000-0002-7443-6697)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Metabolism
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.metabol.2025.156175
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China