Remnant cholesterol concentrations best explain the cardiovascular benefit of APOC3 genetic inhibition: A drug target Mendelian Randomization study
Remnant cholesterol best explains the mechanism through which APOC3 inhibition could prevent CAD. APOC3 inhibition may influence fasting remnant cholesterol to a greater extent than non-fasting remnant cholesterol. People with high levels of remnant cholesterol could benefit from APOC3 inhibition.
Authors
- Éloi Gagnon (ORCID: https://orcid.org/0000-0002-7483-1371)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Benoît J. Arsenault (ORCID: https://orcid.org/0000-0003-2240-8456)
- Stephen Burgess (ORCID: https://orcid.org/0000-0001-5365-8760)
Institutions
- University of Cambridge (GB)
- MRC Biostatistics Unit (GB)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
- Imperial College London (GB)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1093/ehjopen/oeaf018
- Citations
- 4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 8.03