Haptoglobin in pregnancy: Trimester-specific reference intervals
Although overall haptoglobin RI during pregnancy aligned with the nonpregnant population, our study revealed a significant shift during the second trimester. This finding suggests that pregnant individuals in the second trimester may have lower haptoglobin values and potentially be misdiagnosed with intravascular hemolysis when consequent added factors further decrease haptoglobin below the level of detection without hemolysis.
Authors
- Joe M El-Khoury (ORCID: https://orcid.org/0000-0002-9444-9540)
- Ibrahim Choucair (ORCID: https://orcid.org/0000-0003-3540-2811)
- Cristina A. Figueroa Villalba (ORCID: https://orcid.org/0009-0004-1870-4708)
- Michael A. Vera (ORCID: https://orcid.org/0000-0002-6162-7080)
- Edward S. Lee (ORCID: https://orcid.org/0000-0003-1723-4463)
- Maria Rivera (ORCID: https://orcid.org/0009-0003-9671-0938)
Institutions
- University of Kentucky (US)
- Yale University (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1093/ajcp/aqaf012
- Citations
- 4
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 4.61