C-terminal binding protein-2 triggers CYR61-induced metastatic dissemination of osteosarcoma in a non-hypoxic microenvironment
Our findings identify for the first time that CtBP2 acts as a required critical inducing factor in the CYR61-related metastatic progression of osteosarcoma, by favoring cell migration and invasiveness. Moreover, we demonstrate that while CtBP2 is a downstream transcriptional target of CYR61 signaling cascade, it occurs only under non-hypoxic conditions. The present study suggests that CtBP2 may represent a potential pivotal target for therapeutic management of metastases spreading in osteosarcoma.
Authors
- Olivia Fromigué (ORCID: https://orcid.org/0000-0002-3050-6155)
- Robert Olaso (ORCID: https://orcid.org/0000-0001-7631-9657)
- Catherine Brenner (ORCID: https://orcid.org/0000-0002-7715-0934)
- Bojana Stefanovska (ORCID: https://orcid.org/0000-0003-2212-8200)
- Nadia Habel (ORCID: https://orcid.org/0000-0002-4083-8495)
- Laura Di Patria (ORCID: https://orcid.org/0000-0002-1859-6928)
- Romain Fernandes
Institutions
- Centre National de la Recherche Scientifique (FR)
- Howard Hughes Medical Institute (US)
- Inserm (FR)
- The University of Texas at San Antonio Health Science Center (US)
- University of Urbino (IT)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre National de Recherche en Génomique Humaine (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Département Génétique Animale (FR)
- CEA Paris-Saclay (FR)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13046-025-03350-6
- Citations
- 5
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Fondation de l'Avenir pour la Recherche Médicale Appliquée
- Dipartimento di Scienze Pure e Applicate, Università degli Studi di Urbino Carlo Bo