Using Cyclic Ketones to Synthesize New 3,5,6,7,8,9-Hexahydropyrazolo[ 1,5-a]quinoline Derivatives with Antiproliferative Activities: Morphological Studies
The inhibition assays of the tested compounds demonstrated significant activity against c-Met enzymatic activity, with IC<sub>50</sub> values ranging from 0.25 to 10.30 nM. Additionally, potent inhibition was observed in the prostate PC-3 cell line, with IC<sub>50</sub> values ranging from 0.19 to 8.62 μM. These promising results highlight the potential of these compounds and encourage further research to explore their therapeutic applications in the future.
Authors
- Nadia Y. Megally Abdo (ORCID: https://orcid.org/0000-0003-0130-5060)
- Marwa S. Gamaan
- Rafat M. Mohareb
- Ibram Refat Mikhail
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Cairo University (EG)
- Alexandria University (EG)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-03-04
- DOI
- https://doi.org/10.2174/0115680096356497250210064209
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00