Role of the suppressor of cytokine signaling-3 in the pathogenesis of Graves’ orbitopathy
<i>SOCS3</i> was remarkably expressed in the adipose tissues of patients with GO and was induced by IL-1β and IGF-1 in orbital fibroblasts. SOCS3 inhibition attenuated the production of proinflammatory cytokines and adipogenesis, suggesting that <i>SOCS3</i> may be a therapeutic target for controlling the inflammatory and adipogenic mechanisms in GO.
Authors
- Mi-Kyoung Seo (ORCID: https://orcid.org/0000-0002-9372-9313)
- Jin Sook Yoon (ORCID: https://orcid.org/0000-0002-8751-9467)
- Yong Joon Kim (ORCID: https://orcid.org/0000-0001-6090-2549)
- Cheol Ryong Ku (ORCID: https://orcid.org/0000-0001-8693-9630)
- Won-Jin Kim (ORCID: https://orcid.org/0000-0003-2473-815X)
- Eun Jig Lee (ORCID: https://orcid.org/0000-0002-9876-8370)
- Sang Woo Kim (ORCID: https://orcid.org/0000-0002-3144-4822)
- Soo Hyun Choi (ORCID: https://orcid.org/0000-0003-1421-5283)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Yonsei University (KR)
- CHA University (KR)
- CHA University Gangnam Medical Center (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.3389/fendo.2025.1527275
- Citations
- 3
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Research Foundation of Korea
- Yonsei University College of Medicine