Burden and determinants of multi-b/tsDMARD failure in psoriatic arthritis
In this cohort, 17% patients with PsA experienced multi-b/tsDMARD failure. These patients were more likely to be female, obese, and have higher rates of axial involvement and depression, along with higher active disease activity. This highlights the inflammatory and non-inflammatory drivers of multiple therapeutic failures, underscoring the need for precision medicine strategies and potential non-pharmacologic adjuvant therapies for patients with PsA to improve outcomes and quality of life.
Authors
- Rebecca H. Haberman (ORCID: https://orcid.org/0000-0002-7119-8136)
- Samrachana Adhikari (ORCID: https://orcid.org/0000-0001-9954-5999)
- Seungha Um
- K. K. Chen
- José U. Scher (ORCID: https://orcid.org/0000-0002-1072-6994)
- Catherine Howe (ORCID: https://orcid.org/0000-0002-5194-4031)
- Andrea L. Neimann (ORCID: https://orcid.org/0000-0002-9729-0109)
- Biqi Fu (ORCID: https://orcid.org/0000-0001-8960-473X)
- Soumya M. Reddy (ORCID: https://orcid.org/0000-0002-8689-0387)
- Stephanie Eichman
- Adamary Felipe
- Eileen Lydon
- Margaret Coyle
Institutions
- New York University (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13075-025-03518-7
- Citations
- 11
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 18.35
Funders
- National Psoriasis Foundation
- Rheumatology Research Foundation
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases