Update on the Role of Cellular Redox System in Health and Illness

An imbalance between Reactive Oxygen Species (ROS) and antioxidants in the circulatory system leads to oxidative stress, which has been linked to several pathological conditions, including cancer, aging, and neurological and cardiovascular diseases. Antioxidants play a crucial role in re-ducing oxidative damage by neutralizing harmful free radicals and preventing cellular injury. The processes generating cellular oxidative stress and the curative effects of antioxidants, the origins and effects of reactive oxygen species (ROS), the role that oxidative stress plays in the pathogenesis of disease, and the several kinds of antioxidants-including enzymatic and non-enzymatic antioxidants are thoroughly explored in this review. We also emphasized the medicinal uses of antioxidants, both natural and synthetic, in the prevention and treatment of disorders associated with oxidative stress. Furthermore, we discussed the challenges and potential paths ahead for antioxidant research, such as developing new antioxidant molecules with higher efficacy and improving antioxidant delivery sys-tems. This study provides information regarding the complicated dynamics of oxidative stress and the potential benefits of antioxidants for preserving cellular homeostasis and advancing human health.

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Publication Details

Journal
Current Drug Discovery Technologies
Published
2025-03-04
DOI
https://doi.org/10.2174/0115701638349511250121114323
Citations
1
Primary Topic
Free Radicals and Antioxidants
Type
article
Field-Weighted Citation Impact
0.94
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article

Update on the Role of Cellular Redox System in Health and Illness

Kalpana Rahate, Manvi Karayat, Shristi Singh
1 citations
Current Drug Discovery Technologies
Free Radicals and Antioxidants
0.94
article

Update on the Role of Cellular Redox System in Health and Illness

Kalpana Rahate, Manvi Karayat, Shristi Singh
article en
1 citations

Abstract

An imbalance between Reactive Oxygen Species (ROS) and antioxidants in the circulatory system leads to oxidative stress, which has been linked to several pathological conditions, including cancer, aging, and neurological and cardiovascular diseases. Antioxidants play a crucial role in re-ducing oxidative damage by neutralizing harmful free radicals and preventing cellular injury. The processes generating cellular oxidative stress and the curative effects of antioxidants, the origins and effects of reactive oxygen species (ROS), the role that oxidative stress plays in the pathogenesis of disease, and the several kinds of antioxidants-including enzymatic and non-enzymatic antioxidants are thoroughly explored in this review. We also emphasized the medicinal uses of antioxidants, both natural and synthetic, in the prevention and treatment of disorders associated with oxidative stress. Furthermore, we discussed the challenges and potential paths ahead for antioxidant research, such as developing new antioxidant molecules with higher efficacy and improving antioxidant delivery sys-tems. This study provides information regarding the complicated dynamics of oxidative stress and the potential benefits of antioxidants for preserving cellular homeostasis and advancing human health.

Current Drug Discovery TechnologiesVol. 22(5)
Galgotias University (IN)
Openalex Percentile: Top 28%
Free Radicals and Antioxidants
0.94
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