Synthesis of Substituted Quinolines Using the Friedlander Reaction Under Microwave Irradiation Techniques

3-(N-morpholino)propanesulfonic acid (MOPS), used as an organocatalyst supported on acidic alumina (Al<sub>2</sub>O<sub>3</sub>), has been effectively employed for the synthesis of substituted quinolines through the Friedlander reaction under microwave irradiation. The process involves the cyclocondensation of 2-aminoaryl ketones with carbonyl-functionalized active methylene groups. The catalytic efficacy of the MOPS/Al<sub>2</sub>O<sub>3</sub> system proves compatible with this cyclocondensation reaction, offering several advantages including rapid activation of reactants, maintenance of a near-neutral pH, costeffectiveness, and high yield.