Association of NR1I2 Polymorphism with Midazolam Clearance in Mechanically Ventilated ICU Patients: A Population Pharmacokinetic and Pharmacogenetic Study
The PopPK model highlights the significant impact of NR1I2 rs2461817 polymorphism on MDZ CL in Chinese MV patients, emphasizing the need to consider genetic and clinical factors for optimizing MDZ dosing in ICU settings.
Authors
- Maobai Liu (ORCID: https://orcid.org/0000-0002-8382-7868)
- Helin Xie
- Qinyong Weng
- Xuemei Wu (ORCID: https://orcid.org/0009-0003-0895-9849)
- You Zheng (ORCID: https://orcid.org/0000-0001-8169-9412)
- Hui Zhang (ORCID: https://orcid.org/0000-0003-2613-2960)
- Yan-Mei Guo
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s495647
- Citations
- 2
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 4.38