Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque
Our study demonstrated that CD16/32-modified ZIF90 nanoparticles could effectively target macrophages within atherosclerotic plaques, leading to the inhibition of atherosclerotic plaque progression in ApoE<sup>-/-</sup> mice. These effects were attributed to the enhancement of mitochondrial function and the inhibition of macrophage ferroptosis, with limited side effects.
Authors
- Meng-Yang Wang
- Quan Lin (ORCID: https://orcid.org/0000-0003-3693-9311)
- Biyi Xu
- Yuwu Chen (ORCID: https://orcid.org/0000-0002-4025-932X)
- Xiaoxuan Bai
- Xiuzhu Weng
- Yuxiao Zhu (ORCID: https://orcid.org/0000-0002-6757-0935)
- Xing Luo (ORCID: https://orcid.org/0000-0003-1096-6629)
- Man Li (ORCID: https://orcid.org/0000-0003-4041-0437)
- Changqing Xu (ORCID: https://orcid.org/0000-0002-2088-7628)
- Jie Du
- Yuehong Wang (ORCID: https://orcid.org/0009-0007-2363-3723)
- Xinxin Zhu (ORCID: https://orcid.org/0000-0002-7086-1071)
- Ying Lv (ORCID: https://orcid.org/0000-0001-5206-8638)
- Junke Mou
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12951-025-03271-8
- Citations
- 10
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 15.18
Funders
- Key Laboratory of Myocardial Ischemia, Ministry of Education