Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments

ALDH2 may serve as a novel target for the treatment of kidney transplantation AKI, and increasing the expression level of ALDH2 has a protective effect on renal IRI, and this protective effect may be achieved by inhibiting the MAPK signaling pathway.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-03-04
DOI
https://doi.org/10.3389/fimmu.2025.1536800
Primary Topic
Organ Transplantation Techniques and Outcomes
Type
article
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0.00
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article

Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments

Guohua Zhu, Moudong Wu, Jun Pei, Xiong Zhan et al.
Frontiers in Immunology
Organ Transplantation Techniques and Outcomes
article

Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments

Guohua Zhu, Moudong Wu, Jun Pei, Xiong Zhan, Shili Wang, Wei Qiang Wang, Hongyu Tang, Jinpu Peng, Xingyu Pan, Nini An, Dan Wang
article en

Abstract

ALDH2 may serve as a novel target for the treatment of kidney transplantation AKI, and increasing the expression level of ALDH2 has a protective effect on renal IRI, and this protective effect may be achieved by inhibiting the MAPK signaling pathway.

Frontiers in ImmunologyVol. 16
Guizhou Provincial People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 93%
Organ Transplantation Techniques and Outcomes
DOIOpen Access PDFOpenAlex
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Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments — Guohua Zhu, Moudong Wu, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS