Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape
Tat expression in HIV infection may constitute a key epigenetic modelling actor that contributes to HIV pathogenesis and chronic inflammation. Clinical interventions targeting Tat blockade may reduce chronic inflammation and cellular senescence related to HIV infection comorbidities.
Authors
- Víctor Casanova (ORCID: https://orcid.org/0000-0002-4917-260X)
- Mayte Coiras (ORCID: https://orcid.org/0000-0001-6464-5770)
- Angelika Merkel (ORCID: https://orcid.org/0000-0001-5164-6803)
- Núria Climent (ORCID: https://orcid.org/0000-0002-0791-656X)
- Francisco Díez‐Fuertes (ORCID: https://orcid.org/0000-0003-2413-9229)
- Izar Villasante (ORCID: https://orcid.org/0000-0001-7325-0631)
- José Alcamı́ (ORCID: https://orcid.org/0000-0003-0023-7377)
- Andrea Rodríguez-Agustín
- Rubén Ayala-Suárez (ORCID: https://orcid.org/0000-0002-1271-6466)
- María José Maleno (ORCID: https://orcid.org/0000-0002-7882-9973)
Institutions
- Instituto de Salud Carlos III (ES)
- Josep Carreras Leukaemia Research Institute (ES)
- Centro Nacional de Microbiologia (ES)
- Centro de Investigación Biomédica en Red (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1532692
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Gilead Sciences