Long-term effectiveness, adherence and safety of twice-yearly paliperidone-palmitate long acting-injectable in patients with schizophrenia in Europe: 2-year mirror-image data from the paliperdone-2 per year study (P2Y)
This is the first mirror-image study in patients with schizophrenia treated with PP6M in real-world settings showing very high treatment persistence, reduced hospital admissions compared to previous LAIs and no major safety concerns. Our findings suggest that six-monthly treatment with a long-acting antipsychotic may confer additional benefits in the management of schizophrenia. Nonetheless, we were unable to determine the precise changes in symptoms. Therefore, future studies are needed to truly establish the role of PP6M.
Authors
- Ana Arance (ORCID: https://orcid.org/0000-0003-2896-1957)
- Sofia Pappa (ORCID: https://orcid.org/0000-0002-6303-1547)
- Aquilino Polaino Lorente
- Rocío Sáez Povedano
- Guillermo Isidro García (ORCID: https://orcid.org/0000-0002-1954-5196)
- Laura Mata Iturralde (ORCID: https://orcid.org/0000-0001-6847-1229)
- Javier Vázquez-Bourgón (ORCID: https://orcid.org/0000-0002-5478-3376)
- María Pilar Campos-Navarro (ORCID: https://orcid.org/0000-0001-8063-3235)
- Juan Antonio García-Carmona (ORCID: https://orcid.org/0000-0003-3938-7698)
- Enrique Baca‐García (ORCID: https://orcid.org/0000-0002-6963-6555)
- Miguel Barberán Navalón
- Sergio Sánchez-Alonso
- Paula Suárez‐Pinilla (ORCID: https://orcid.org/0000-0002-2869-1718)
- Sergio Benavente-López
- Claudia Ovejas-Catalán
- Paloma Fuentes-Pérez
- Blanca Fernández Abascal
- Alberto Raya Platero
- Luis Alberto Forcen-Muñoz
- Ana Luisa González-Galdámez
- Mariluz Ramirez Bonilla
- Santiago Ovejero García
- Miguel Omaña Colmenares
- A. García-Pérez
- Sofía Manchado Perero
Institutions
- Universidad de Cantabria (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Marqués de Valdecilla University Hospital (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Centro Tecnológico Nacional de la Conserva y Alimentación (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital General Universitario Los Arcos del Mar Menor (ES)
- Santa Lucía University General Hospital (ES)
- Hospital Universitario Lluís Alcanyís (ES)
- West London Mental Health NHS Trust (GB)
- Hospital Universitario Infanta Leonor (ES)
- Imperial College London (GB)
- Universidad Católica de Murcia (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-03-04
- DOI
- https://doi.org/10.3389/fpsyt.2025.1540213
- Citations
- 3
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41