Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas–FasL pathway activation and metabolic reprogramming
Our study demonstrates that DHP effectively inhibits the proliferation and induces apoptosis in HCT116 colon cancer cells through the activation of the Fas-FasL signaling pathway and metabolic reprogramming. The selective inhibitory effect of DHP on HCT116 cells, the activation of both death receptor and mitochondrial apoptotic pathways, and the modulation of metabolic reprogramming provide novel insights into the potential therapeutic strategies for colon cancer.
Authors
- G Li
- Daiyin Peng (ORCID: https://orcid.org/0000-0002-8734-0897)
- Xiangjiao Meng (ORCID: https://orcid.org/0000-0001-7380-5510)
- Ruipeng Ge
- Liang Yao (ORCID: https://orcid.org/0009-0006-5175-4859)
- Chen Gu (ORCID: https://orcid.org/0000-0002-0241-3197)
- Xiaoqian Zhang (ORCID: https://orcid.org/0000-0002-3830-3651)
- Lei Wang (ORCID: https://orcid.org/0000-0001-5668-4737)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.3389/fonc.2025.1529868
- Citations
- 1
- Primary Topic
- Biological and pharmacological studies of plants
- Type
- article
- Field-Weighted Citation Impact
- 1.39