Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis
Reduced biologically active vitamin D in circulation suggests its impaired metabolism in IIM. Serum vitamin D levels and gene expression of its receptor and activating enzyme in muscle tissue were modified by regular exercise and associated with disease manifestations, physical fitness, and muscle lipid metabolism of IIM patients.
Authors
- Barbara Ukropcová (ORCID: https://orcid.org/0000-0002-3309-7713)
- Kateřina Kubínová (ORCID: https://orcid.org/0000-0002-3175-1419)
- Michal Nemec
- Jozef Ukropec (ORCID: https://orcid.org/0000-0001-8401-6621)
- Veronika Horváthová
- Maja Špiritović (ORCID: https://orcid.org/0000-0002-9114-2172)
- Nikoleta Alchus Laiferová (ORCID: https://orcid.org/0000-0001-6605-8967)
- Michal Tomčík (ORCID: https://orcid.org/0000-0002-8616-7850)
- Sabína Oreská (ORCID: https://orcid.org/0000-0002-9912-725X)
- Lucia Vernerová (ORCID: https://orcid.org/0000-0001-6087-2175)
- Martin Klein (ORCID: https://orcid.org/0000-0002-1027-0923)
- Martina Vokurková (ORCID: https://orcid.org/0000-0002-7669-0648)
- Jiří Vencovský (ORCID: https://orcid.org/0000-0002-0851-0713)
- László Wenchich (ORCID: https://orcid.org/0000-0002-8250-2981)
- Tereza Kropáčková
- Oksana Mytiai
Institutions
- Slovak Academy of Sciences (SK)
- Charles University (CZ)
- Institute of Rheumatology (CZ)
- Institute of Experimental Endocrinology of the Slovak Academy of Sciences (SK)
- Czech Technical University in Prague (CZ)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13075-025-03516-9
- Citations
- 4
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Ministerstvo Zdravotnictví Ceské Republiky
- Agentúra na Podporu Výskumu a Vývoja
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV