Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory
These findings highlight the crucial role of dvCA1<sup>Calb1-</sup> neurons in the early stage of tau pathology and demonstrate the potential of targeting phosphorylated tau through MARK4 knockdown or DEPTAC administration to counter the vulnerability of dvCA1<sup>Calb1-</sup> neurons and, consequently, ameliorate episodic memory deficits in AD.
Authors
- Fuqiang Zhang (ORCID: https://orcid.org/0000-0002-2627-5876)
- Ai‐Min Bao (ORCID: https://orcid.org/0000-0002-8755-1950)
- Peiran Jiang
- Jingru Lv
- Huiyang Lei (ORCID: https://orcid.org/0000-0002-9157-7301)
- Tao Zhong (ORCID: https://orcid.org/0000-0002-6991-2521)
- Ying Yang (ORCID: https://orcid.org/0000-0002-9479-4766)
- Rui Xiong (ORCID: https://orcid.org/0000-0003-3268-9618)
- Fei Sun (ORCID: https://orcid.org/0000-0001-8184-6718)
- Qun Wang (ORCID: https://orcid.org/0000-0001-7929-7692)
- Jian‐Zhi Wang (ORCID: https://orcid.org/0009-0000-2068-6749)
- Jiale Liu (ORCID: https://orcid.org/0009-0007-7615-833X)
- Kun Shi (ORCID: https://orcid.org/0000-0003-4183-5429)
- Dan Ke
- Linyu Wei (ORCID: https://orcid.org/0000-0003-4773-2228)
- Ting He (ORCID: https://orcid.org/0000-0001-6171-8225)
- Jingqi Zhao
Institutions
- Nantong University (CN)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s40035-025-00473-w
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen