The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation
M2 macrophage-derived exosomes miR-34a-5p could aggravate the development of urethral fibrosis and stricture by blocking autophagosome-lysosome fusion in urethral fibroblasts and further accelerating fibrogenesis by directly targeting SIRT1, suggesting that M2-Exo miR-34a-5p and SIRT1 could serve as promising therapeutic targets for urethral stricture.
Authors
- Yisheng Yin (ORCID: https://orcid.org/0009-0000-8168-0586)
- Zhixian Wang (ORCID: https://orcid.org/0000-0002-0515-8312)
- Huizhi Wei
- Chang Liu (ORCID: https://orcid.org/0000-0002-2957-0897)
- Jing Wang (ORCID: https://orcid.org/0000-0003-1580-1356)
- Li Xing (ORCID: https://orcid.org/0000-0002-4759-7380)
- Shiliang Liu (ORCID: https://orcid.org/0000-0002-1908-7826)
- Xiang Ren (ORCID: https://orcid.org/0000-0003-2677-0823)
- Yiqun Tian (ORCID: https://orcid.org/0000-0002-8221-2087)
- Yunpeng Zhu (ORCID: https://orcid.org/0000-0002-8490-3973)
- Xiaoyong Zeng
- Chunxiang Feng
- Minglong Wu
Institutions
- Shanxi Medical University (CN)
- Wuhan No.1 Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/itt.s500499
- Citations
- 2
- Primary Topic
- Urological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.67