Differences in innate immune cell populations distinguish autoimmune from herpesvirus-associated encephalitis
AIE is characterized by a B and T cell-mediated systemic and intrathecal immune-cell signature which corresponds to changes reported in the brain parenchyma providing insights into immunopathogenesis. Differences between AIE and VME were most prominent for the innate immune response indicating a potential role of NK cells in the pathogenesis of autoimmunity. Our data provides evidence that mFC could be a novel complementary approach to the diagnosis of AIE with diagnostic, therapeutic, and prognostic implications.
Authors
- Kristin S. Golombeck
- Christina B. Schroeter (ORCID: https://orcid.org/0000-0002-1391-7817)
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Kelvin Sarink (ORCID: https://orcid.org/0000-0002-4840-5619)
- Heinz Wiendl (ORCID: https://orcid.org/0000-0003-4310-3432)
- Saskia Räuber (ORCID: https://orcid.org/0000-0001-8901-5572)
- Tobias Ruck (ORCID: https://orcid.org/0000-0001-6332-8650)
- Oliver Grauer
- Andreas Schulte‐Mecklenbeck (ORCID: https://orcid.org/0000-0003-3855-4706)
- Tim Hahn (ORCID: https://orcid.org/0000-0001-6541-3795)
- Andre Dik (ORCID: https://orcid.org/0000-0003-4695-4136)
- Christopher Nelke (ORCID: https://orcid.org/0000-0002-6048-7143)
- Catharina C. Groß (ORCID: https://orcid.org/0000-0002-4872-9189)
- Udo Dannlowski (ORCID: https://orcid.org/0000-0002-0623-3759)
- Alice Willison (ORCID: https://orcid.org/0000-0002-0719-8334)
- Nico Melzer (ORCID: https://orcid.org/0000-0002-2420-701X)
- Christine Strippel (ORCID: https://orcid.org/0000-0002-7080-6769)
- Gerd Meyer zu Hörste (ORCID: https://orcid.org/0000-0002-4341-4719)
- Marco Gallus (ORCID: https://orcid.org/0009-0007-4954-8420)
- Stjepana Kovac (ORCID: https://orcid.org/0000-0002-5571-9237)
Institutions
- University of Münster (DE)
- Düsseldorf University Hospital (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jaut.2025.103396
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00