CD36 promotes iron accumulation and dysfunction in CD8+ T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma
Our findings reveal a previously unidentified mechanism mediated by CD36 that regulates the progressive dysfunction of CD8+ T cells in early HCC TME and provide a potential novel therapeutic approach to restore T cell function.
Authors
- Jiali Yang (ORCID: https://orcid.org/0000-0002-1560-7660)
- Ziwei Yang (ORCID: https://orcid.org/0000-0003-3362-0946)
- Jiao Wu (ORCID: https://orcid.org/0000-0002-9718-5499)
- Ruibin Yang (ORCID: https://orcid.org/0000-0003-0888-6347)
- Gang Nan (ORCID: https://orcid.org/0000-0002-7926-4572)
- Peng‐Chan Lin (ORCID: https://orcid.org/0000-0002-9424-1985)
- Ling‐Min Kong (ORCID: https://orcid.org/0000-0003-2560-4540)
- Yaxin Ding
- Gang Zhou (ORCID: https://orcid.org/0000-0001-8633-6290)
- Huijie Bian (ORCID: https://orcid.org/0000-0003-4690-4622)
- Jialu Hou (ORCID: https://orcid.org/0000-0003-4737-7721)
- Zhi‐Nan Chen (ORCID: https://orcid.org/0000-0001-5512-4623)
- Ding‐Qiao Xu
- Yifei Qin (ORCID: https://orcid.org/0000-0003-0028-208X)
- Xiaohang Xie
- Jian-Li Jiang
- Fei Huo (ORCID: https://orcid.org/0000-0002-3402-2190)
- Shijie Wang
- Ling Li (ORCID: https://orcid.org/0000-0002-1940-8693)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-9797-0753)
- Qian He (ORCID: https://orcid.org/0000-0003-4346-9899)
- Quancheng Wang (ORCID: https://orcid.org/0000-0002-9571-676X)
- Yu Gui (ORCID: https://orcid.org/0000-0003-0255-0308)
- Zhuan Feng
Institutions
- Jinan University (CN)
- National Medical Products Administration (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Center for Discovery (US)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.3350/cmh.2024.0948
- Citations
- 17
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 17.77