Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity
These findings demonstrate that hypoxanthine in the bone marrow supernatant acts as a signaling mediator under microgravity, influencing HSCs fate by modulating hematopoietic cell lineage and MAPK signaling pathways. This study offers novel insights into the impact of microgravity on HSC fate and gene expression, underscoring the pivotal role of bone marrow microenvironmental metabolic changes in regulating key signaling pathways that determine hematopoietic destiny.
Authors
- Penghui Ye (ORCID: https://orcid.org/0000-0001-5053-4746)
- Jinxiao Yan
- Yanran Wang
- Zhenhao Tian (ORCID: https://orcid.org/0000-0001-8204-4186)
- Hui Yang (ORCID: https://orcid.org/0000-0001-7567-3048)
- Bin Liu (ORCID: https://orcid.org/0000-0003-1569-2604)
- Hao Zhang (ORCID: https://orcid.org/0000-0001-9366-7151)
- Nu Zhang (ORCID: https://orcid.org/0000-0003-1285-0785)
- Xiru Liu (ORCID: https://orcid.org/0000-0003-1742-5833)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Northwestern Polytechnical University (CN)
- Chinese People's Armed Police Force Medical College Affiliated Hospital (CN)
- Logistics University of People's Armed Police Force (CN)
- Chinese People's Armed Police General Hospital (CN)
- Ministry of Education (TW)
- Northwestern Polytechnic University (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13287-025-04213-9
- Citations
- 4
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Foundation for the Author of National Excellent Doctoral Dissertation of the People's Republic of China
- Natural Science Foundation of Shaanxi Provincial Department of Education
- Fundamental Research Funds for the Central Universities