Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX3CR1+ synovial lining macrophage barrier
Our results suggest that ADSCs ameliorated the energy metabolism signature of CX<sub>3</sub>CR1<sup>+</sup> lining macrophages and may promote barrier restoration through mitochondria transfer. In addition, we elucidated the fate of ADSCs and the therapeutic potential of mitochondria in RA treatment.
Authors
- Zhang Xue (ORCID: https://orcid.org/0000-0002-6524-5549)
- Yongyue Xu (ORCID: https://orcid.org/0009-0005-8239-8968)
- Zhaoyan Wang (ORCID: https://orcid.org/0000-0002-0977-0920)
- Hanqi Xie (ORCID: https://orcid.org/0000-0003-3116-3294)
- Ming Hao (ORCID: https://orcid.org/0000-0003-0733-7178)
- Qiong Wu (ORCID: https://orcid.org/0000-0003-2244-4350)
- Jianbin Wang (ORCID: https://orcid.org/0000-0001-6725-7925)
- Jun Lin (ORCID: https://orcid.org/0000-0002-5152-6518)
- Xiaodan Sun
- Lei Wang (ORCID: https://orcid.org/0000-0002-4705-0908)
- Bo Zhang (ORCID: https://orcid.org/0000-0001-8012-0560)
Institutions
- Soochow University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13287-025-04144-5
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Horizon 2020 Framework Programme