Preclinical study of engineering MSCs promoting diabetic wound healing and other inflammatory diseases through M2 polarization
In summary, our study demonstrates that genetically modified hUMSCs effectively overexpressed three key anti-inflammatory factors (IL-4, IL-10, IL-13). MSCs-3IL-based therapy enhances diabetic wound healing with high efficiency and safety. This suggests that genetically modified hUMSCs could be used as a novel therapeutic approach for DFU repair.
Authors
- Hongjie Xu (ORCID: https://orcid.org/0000-0001-9266-0740)
- Rencun Liu
- Xiaotong Cen (ORCID: https://orcid.org/0000-0002-7486-136X)
- Yixia Ling
- Huanxing Su (ORCID: https://orcid.org/0000-0003-3254-825X)
- Wanwen Dong
- Dajiang Qin (ORCID: https://orcid.org/0009-0008-2792-3514)
- Rui Mao (ORCID: https://orcid.org/0000-0002-1022-306X)
- Di Wu (ORCID: https://orcid.org/0000-0003-2462-4232)
- Sun Haitao
- Jiali Lin
- Qing Chen (ORCID: https://orcid.org/0000-0003-2425-9378)
- Rui Huang (ORCID: https://orcid.org/0000-0003-0786-8163)
- Xia Wang (ORCID: https://orcid.org/0000-0002-3769-1293)
Institutions
- Huanggang Normal University (CN)
- Sun Yat-sen University (CN)
- Linyi University (CN)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- University of Macau (MO)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Zhujiang Hospital (CN)
- Tongji Hospital (CN)
- Shanghai Huangpu District Central Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
- China National Petroleum Corporation (China) (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13287-025-04248-y
- Citations
- 18
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 29.26
Funders
- Innovation and Technology Commission - Hong Kong
- Department of Education of Guangdong Province
- Guangzhou Municipal Health and Family Planning Commission
- Guangzhou Municipal Science and Technology Project