Exosomal miR-125b-5p derived from mesenchymal stromal/stem cell enhances anti-PD-1 therapy in mouse colon cancer model
In summary, our findings suggest that exosomal miR-125b-5p derived from MSC exerts prominent potential in advancing anti-PD-1 therapy by modulating tumor immune environment. This property of miR-125b-5p may be therapeutically harnessed in human cancers to enhance the efficacy of immunotherapy.
Authors
- Xueqin Yan
- Mengmeng Jiang (ORCID: https://orcid.org/0000-0002-9069-0150)
- Zhengzhi Wu (ORCID: https://orcid.org/0000-0002-8819-609X)
- Jia Liu (ORCID: https://orcid.org/0000-0001-7776-0794)
- Yongkai Cao
- Shengquan Hu
Institutions
- Changchun University of Chinese Medicine (CN)
- Ningbo College of Health Sciences (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13287-025-04227-3
- Citations
- 8
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China