Integration of multi-omics data accelerates molecular analysis of common wheat traits
Integration of multi-omics data can provide information on biomolecules from different layers to illustrate the complex biology systematically. Here, we build a multi-omics atlas containing 132,570 transcripts, 44,473 proteins, 19,970 phosphoproteins, and 12,427 acetylproteins across wheat vegetative and reproductive phases. Using this atlas, we elucidate transcriptional regulation network, contributions of post-translational modification (PTM) and transcript level to protein abundance, and biased homoeolog expression and PTM in wheat. The genes/proteins related to wheat development and disease resistance are systematically analyzed, thus identifying phosphorylation and/or acetylation modifications for the seed proteins controlling wheat grain quality and the disease resistance-related genes. Lastly, a unique protein module TaHDA9-TaP5CS1, specifying de-acetylation of TaP5CS1 by TaHDA9, is discovered, which regulates wheat resistance to Fusarium crown rot via increasing proline content. Our atlas holds great promise for fast-tracking molecular biology and breeding studies in wheat and related crops.
Authors
- Armin Soleymaniniya (ORCID: https://orcid.org/0000-0002-7799-6091)
- Songgang Li (ORCID: https://orcid.org/0009-0008-6556-0566)
- Sisheng Wang (ORCID: https://orcid.org/0000-0002-4166-9777)
- Xia V. Yang (ORCID: https://orcid.org/0009-0009-2506-8371)
- Feng Chen (ORCID: https://orcid.org/0000-0002-7327-2969)
- Lingran Zhang (ORCID: https://orcid.org/0000-0002-8936-0904)
- Wenkang Wang (ORCID: https://orcid.org/0000-0002-6325-1267)
- Mathias Wilhelm (ORCID: https://orcid.org/0000-0002-9224-3258)
- Ruiqing Zheng (ORCID: https://orcid.org/0000-0001-6372-6798)
- Mengjuan Gao
- Daiying Chen (ORCID: https://orcid.org/0009-0002-1763-0781)
- Li Tang (ORCID: https://orcid.org/0000-0002-6393-982X)
- Yichao Zhao (ORCID: https://orcid.org/0000-0003-1058-0865)
- Lu Liu (ORCID: https://orcid.org/0000-0002-0722-9241)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-0481-6336)
- Yan Ren (ORCID: https://orcid.org/0000-0002-8327-5346)
- Min Li (ORCID: https://orcid.org/0000-0002-0188-1394)
- Congwei Sun
- Daowen Wang (ORCID: https://orcid.org/0000-0002-6230-8735)
Institutions
- Central South University (CN)
- Henan Agricultural University (CN)
- Technical University of Munich (DE)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1038/s41467-025-57550-x
- Citations
- 28
- Primary Topic
- Wheat and Barley Genetics and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 48.99