Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts
While this study did not observe significant changes in primary or secondary endpoints, it suggests that a short-term high-fiber intervention may induce beneficial shifts in gut microbiota and microbial metabolites in individuals with PWS. Further research is warranted to investigate the long-term effects and potential therapeutic applications of fiber interventions in PWS.
Authors
- Edward C. Deehan (ORCID: https://orcid.org/0000-0001-7697-1418)
- B Ho (ORCID: https://orcid.org/0000-0003-4694-945X)
- Flávio Teixeira Vieira (ORCID: https://orcid.org/0000-0001-6770-0640)
- Mohammadreza Pakseresht (ORCID: https://orcid.org/0000-0003-1356-9135)
- Karen Madsen (ORCID: https://orcid.org/0000-0002-8636-0714)
- Andrea Maria Haqq (ORCID: https://orcid.org/0000-0002-6256-4982)
- Shima Afhami (ORCID: https://orcid.org/0000-0002-6074-3717)
- Olga Ilkayeva (ORCID: https://orcid.org/0000-0002-9779-0883)
- Jens Walter (ORCID: https://orcid.org/0000-0003-1754-172X)
- Qiming Tan (ORCID: https://orcid.org/0000-0001-9014-6246)
- Christopher B. Newgard (ORCID: https://orcid.org/0000-0002-1293-691X)
- Eytan Wine (ORCID: https://orcid.org/0000-0002-3458-4142)
- Hein M. Tun (ORCID: https://orcid.org/0000-0001-7597-5062)
- Catherine J. Field (ORCID: https://orcid.org/0000-0001-7285-4767)
- Peng Ye (ORCID: https://orcid.org/0000-0001-7150-1265)
Institutions
- University of Nebraska–Lincoln (US)
- University of Alberta (CA)
- University of Calgary (CA)
- Duke University (US)
- Chinese University of Hong Kong (HK)
- University College Cork (IE)
- Duke Medical Center (US)
- Pixel Magic Systems (China) (CN)
- APC Microbiome Institute (IE)
- Duke University Hospital (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1210/clinem/dgaf142
- Citations
- 1
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 1.82