Identification of a new genetic locus associated with atrial fibrillation in the Taiwanese population by genome-wide and transcriptome-wide association studies
Genome-wide association study in Taiwan revealed PITX2 and RAP1A/KCND3 loci and novel AF locus (HNF4G) with the most significant locus in the RAP1A locus. RAP1A and HNF4G genes may implicate fibrosis, metabolic, and neurogenic pathways in pathogenesis of AF.
Authors
- Guan-Wei Li (ORCID: https://orcid.org/0009-0006-4301-5036)
- Fu‐Chun Chiu (ORCID: https://orcid.org/0000-0002-8282-485X)
- Chia‐Ti Tsai (ORCID: https://orcid.org/0000-0002-4853-8665)
- Sheng‐Nan Chang (ORCID: https://orcid.org/0000-0002-2663-5042)
- Chih‐Hsien Wang (ORCID: https://orcid.org/0000-0003-3214-6867)
- Su‐Kiat Chua (ORCID: https://orcid.org/0000-0003-1893-6360)
- Eric Y. Chuang (ORCID: https://orcid.org/0000-0003-2530-0096)
- Jien‐Jiun Chen (ORCID: https://orcid.org/0000-0002-1848-6083)
- Pang‐Shuo Huang (ORCID: https://orcid.org/0000-0002-8210-2486)
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Memorial Hospital (US)
- National Taipei University (TW)
Publication Details
- Journal
- EP Europace
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1093/europace/euaf042
- Citations
- 4
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 7.27