Domain-specific brain regions are associated with cognitive impairment in progressive supranuclear palsy
Diffusion Microstructure Imaging revealed domain-specific regions of neurodegenerative alterations in PSP. The regions identified in this approach integrate well in existing disease concepts. They might therefore be a possible biomarker for cognitive impairment, as well as amonitoring parameter for future disease modifying therapeutics.
Authors
- Panteleimon Oikonomou (ORCID: https://orcid.org/0000-0002-3973-2861)
- Horst Urbach (ORCID: https://orcid.org/0000-0001-7264-4807)
- Wolfgang H. Jost (ORCID: https://orcid.org/0000-0002-8574-3297)
- Cornelius Weiller (ORCID: https://orcid.org/0000-0002-2448-5714)
- M. Reisert
- Michel Rijntjes
- Nils Schröter (ORCID: https://orcid.org/0000-0002-3833-9822)
- Hansjörg Mast (ORCID: https://orcid.org/0009-0008-3744-7304)
- Lars Frings (ORCID: https://orcid.org/0000-0001-9377-8935)
- Alexander Rau (ORCID: https://orcid.org/0000-0001-5881-6043)
- Jonas A. Hosp (ORCID: https://orcid.org/0000-0001-7696-9334)
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Parkinson-Klinik Ortenau (DE)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.ynirp.2025.100247
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Albert-Ludwigs-Universität Freiburg