Frequency and Clinical Significance of Clonal and Subclonal Driver Mutations in High-Risk Neuroblastoma at Diagnosis: A Children's Oncology Group Study
Ultra-deep sequencing of high-risk NBLs demonstrates that oncogenic aberrations are more prevalent at diagnosis than previously recognized. <i>ALK</i> and RAS pathway aberrations confer inferior outcomes in patients treated with contemporary therapy, emphasizing the need for novel therapeutic approaches.
Authors
- Arlene Naranjo (ORCID: https://orcid.org/0000-0001-7737-4324)
- Steven G. DuBois (ORCID: https://orcid.org/0000-0003-0882-738X)
- John M. Maris (ORCID: https://orcid.org/0000-0002-8088-7929)
- Esther R. Berko (ORCID: https://orcid.org/0000-0001-7181-1378)
- Julie R. Park (ORCID: https://orcid.org/0000-0002-6777-9165)
- Samantha N. McNulty (ORCID: https://orcid.org/0000-0003-0004-0697)
- Kristin Zelley (ORCID: https://orcid.org/0000-0003-0970-1850)
- Yaël P. Mossé (ORCID: https://orcid.org/0000-0002-3463-0399)
- Alexander A. Daniels (ORCID: https://orcid.org/0000-0001-7200-9248)
- Balakrishna Koneru (ORCID: https://orcid.org/0000-0002-2163-7049)
- Rochelle Bagatell (ORCID: https://orcid.org/0000-0002-5729-8819)
- Meredith S. Irwin (ORCID: https://orcid.org/0000-0002-2452-5181)
- Kateryna Krytska
- Todd E. Druley (ORCID: https://orcid.org/0000-0002-3245-7561)
- C. Patrick Reynolds (ORCID: https://orcid.org/0000-0002-2827-8536)
- Lulu Chen (ORCID: https://orcid.org/0000-0001-9621-9231)
- Grace Polkosnik (ORCID: https://orcid.org/0000-0001-6631-9995)
Institutions
- Texas Tech University (US)
- St. Jude Children's Research Hospital (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- Tel Aviv University (IL)
- University of Toronto (CA)
- Danaher (United States) (US)
- Hospital for Sick Children (CA)
- University of Florida (US)
- Schneider Children's Medical Center (IL)
- Children's Oncology Group (US)
- SickKids Foundation (CA)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- University of Pennsylvania (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1200/jco-24-02407
- Citations
- 10
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.89