Functional Assessment of Garcinia Cambogia Complex: Implications for Body Fat Reduction

This study evaluated the efficacy of Garcinia cambogia complex (CAC) in preventing body fat accumulation. Male SD rats were used in the experiment, which included a normal diet (ND) group and a high-fat diet (HFD) group. The HFD group was further divided into four subgroups, each receiving a different treatment: 0, 207, 414, and 828 mg/kg of the CAC (1x, 2x, 4x dose). All rats were fed anHFD for 9 weeks, and the treatments were administered from week six onwards. At the end of the experiment, the rats were sacrificed, and analyses were conducted on body weight, body fat mass, serum biochemical values, and liver lipid concentration. The results showed that theCAC significantly reduced the final body weight, body fat mass, body fat percentage, and food utilization rate in the treated rats compared to the HFD control group. Rats in the HFD control group exhibited elevated serum levels of aspartate aminotransferase, alanine aminotransferase (ALT), triglycerides, total cholesterol, low-density lipoprotein, free fatty acids, and glucose compared to the ND group. The 1x dose of the CAC improved these biochemical parameters, except for ALT and glucose levels. The 2x and 4x dose groups showed a significant reduction in blood glucose levels, while the 4x dose group notably decreased serum ALT levels. In conclusion, daily intake of the CAC significantly reduced body fat accumulation in rats, demonstrating potential health benefits in preventing obesity.