Facile Synthesis of Ureidic Derivatives of Betulinic Acid With Antiproliferative Effects on Colorectal and Prostate Cancer Cells

Betulinic acid isolated from Platanus orientalis bark was modified in one-pot reaction to furnish 12 ureidic derivatives. The synthesized derivatives were tested against an array of cancer cell lines, colon HCT-116, breast MCF-7, pancreatic MIA PaCa-2, and prostate PC-3 cancer cell lines. Among the synthesized compounds, BA1 exhibited potent anti-cancer activity with IC₅₀ of 0.84 and 3.87 µM against HCT-116 and PC-3 using doxorubicin as standard. Our study demonstrates the anti-proliferative and anti-metastatic role of BA1, thus inducing apoptosis in prostrate and colorectal cell lines.