Neutrophil-to-Lymphocyte Ratio: Link to Congestion, Inflammation, and Mortality in Outpatients with Heart Failure
Low lymphocyte count is associated with more congestion and high neutrophil count with more inflammation, which may explain why a greater NLR is associated with a poorer prognosis. For patients with heart failure, NLR or its components could be useful for risk stratification or for monitoring evolving risk, but might also be therapeutic targets.
Authors
- Syed Jamil Hasan Kazmi (ORCID: https://orcid.org/0000-0001-5309-4432)
- Antonio Iaconelli (ORCID: https://orcid.org/0000-0001-7413-8449)
- John G.F. Cleland (ORCID: https://orcid.org/0000-0002-1471-7016)
- Armando Ialenti (ORCID: https://orcid.org/0000-0002-8046-0116)
- Tomasz J. Guzik (ORCID: https://orcid.org/0000-0002-5039-7849)
- Pierpaolo Pellicori (ORCID: https://orcid.org/0000-0001-7175-0464)
- Andrew L. Clark (ORCID: https://orcid.org/0000-0001-8362-668X)
- Dario Bruzzese (ORCID: https://orcid.org/0000-0001-9911-4646)
- Elisabetta Caiazzo (ORCID: https://orcid.org/0000-0002-5667-5176)
- Asma O.M. Rezig (ORCID: https://orcid.org/0000-0002-1096-0115)
- Pasquale Maffia (ORCID: https://orcid.org/0000-0003-3926-4225)
- David Hunter (ORCID: https://orcid.org/0000-0003-3518-1529)
- Moustafa I Morsy (ORCID: https://orcid.org/0000-0001-9878-8913)
- Joe Cuthbert
Institutions
- Jagiellonian University (PL)
- University of Hull (GB)
- Castle Hill Hospital (GB)
- Agostino Gemelli University Polyclinic (IT)
- University Alliance (GB)
- Federico II University Hospital (IT)
- The Queen's Medical Research Institute (GB)
- Hull York Medical School (GB)
- University of Naples Federico II (IT)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1002/ehf2.15240
- Citations
- 4
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Università degli Studi di Napoli Federico II
- Compagnia di San Paolo
- British Heart Foundation
- Heart Research UK
- European Commission
- University of Edinburgh
- University of Glasgow
- Ministero dell’Istruzione, dell’Università e della Ricerca
- European Research Area Network on Cardiovascular Diseases
- European Research Council
- Narodowe Centrum Badań i Rozwoju