Identification of Pathogenic <scp>PD</scp>‐1<sup>+</sup><scp>CD8</scp><sup>+</sup> T Cells for Effective Chimeric Antigen Receptor Therapy in a Murine Model of Sjögren Disease
We identified the pathogenic role of PD-1<sup>+</sup>CD8<sup>+</sup> T cells in both patients with SjD and a murine model and demonstrated the efficacy of PD-1-targeted CAR-T cell therapy in SjD model mice. Our findings suggest a promising avenue for developing clinical therapeutic strategies for patients with SjD.
Authors
- Hao‐Xian Zhu
- Zhibin Zhao (ORCID: https://orcid.org/0000-0002-8994-3106)
- Liwei Lu (ORCID: https://orcid.org/0000-0002-8634-0967)
- Cai‐Yue Gao (ORCID: https://orcid.org/0009-0005-8072-8206)
- Zhe‐Xiong Lian (ORCID: https://orcid.org/0000-0002-9525-1421)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Li Yang (ORCID: https://orcid.org/0000-0002-7880-2113)
- Ting Xu (ORCID: https://orcid.org/0000-0002-8485-119X)
- Li Liang (ORCID: https://orcid.org/0000-0001-5302-2754)
- Jin‐Fen Ma
Institutions
- Chinese University of Hong Kong (HK)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Shaanxi Research Association for Women and Family (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- University of Hong Kong (HK)
- South China University of Technology (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1002/art.43144
- Citations
- 1
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China