Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta
This study provides evidence that the human placenta has a distinct Xi DNAme landscape, which may inform our understanding of sex differences during prenatal development. Future research should explore the mechanisms underlying the placenta's unique X-linked DNAme profile, and the factors involved in placental XCI maintenance.
Authors
- Allison Matthews (ORCID: https://orcid.org/0000-0001-8394-0337)
- Melissa A. Wilson (ORCID: https://orcid.org/0000-0002-2614-0285)
- Carolyn J. Brown (ORCID: https://orcid.org/0000-0002-8959-0101)
- Amy M. Inkster (ORCID: https://orcid.org/0000-0002-1120-6624)
- Seema B. Plaisier (ORCID: https://orcid.org/0000-0002-9093-8400)
- Tanya N. Phung (ORCID: https://orcid.org/0000-0003-2685-6977)
- Wendy P. Robinson (ORCID: https://orcid.org/0000-0002-2010-6174)
Institutions
- University of British Columbia (CA)
- BC Children's Hospital (CA)
- Arizona State University (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13293-025-00696-6
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- BC Children's Hospital
- Canadian Institutes of Health Research