An Overview of Therapeutic Potential of Various Quinazoline Alkaloids and its Derivatives Containing Medicinal Plants

Medicinal plants have a wide range of therapeutic and pharmacological value with minimum side effects compared to synthetic drugs. Medicinal plants biosynthesis the secondary metabolites from the primary metabolites, such as alkaloids, glycosides, tannins, resins, etc. Alkaloids are abundantly naturally occurring secondary metabolites with high therapeutic value. Quinazoline alkaloids are two N-fused heterocyclic organic compounds with comparable therapeutic value. Quinazoline alkaloids such as vasicine and febrifugine showed valuable therapeutic effects such as anti-inflammatory, antibacterial, antioxidant and anti-malarial activities in both in-vitro and in-vivo studies. Medicinal plants such as Adhatoda vasica, Dichroa febrifuga and Peganum harmala have valuable therapeutic quinazoline alkaloids. This review article emphasises and explains the various biological sources and families of medicinal plants with quinazoline alkaloids and their therapeutic effects. Major Findings: The present study highlights the key medicinal effects of plants containing quinazoline alkaloids. These plants exhibit diverse pharmacological properties, including bronchodilator, anticancer, antimicrobial, and anti-inflammatory activities. Understanding their therapeutic potential can contribute to developing new drugs and treatments for various diseases.