Research Progress on Correlations between P53 and Colorectal Cancer

Colorectal cancer is currently an important health problem worldwide. However, existing treatments fail to meet the need for a radical cure. Additionally, treatment is limited due to toxic side effects and acquired drug resistance. P53 is a tumor suppressor gene encoding P53 protein, which has a significant potential role in the occurrence, development and treatment of colorectal cancer. Many natural products and compounds have been found to interfere with the progression of colorectal cancer by regulating P53, but systematic reviews are lacking. This study systematically reviewed the introduction of P53, the relationship between P53 and the occurrence, development and treatment of colorectal cancer, and the regulation of P53 by natural products and compounds against colorectal cancer. This provides the theoretical foundation for the treatment of colorectal cancer and offer new ideas for the development of novel therapeutic agents for this disease.