A new view on increasing the effectiveness of treatment of patients with respiratory tuberculosis through correction of autonomic dysfunction of the organism

The aim of the study is to improve the effectiveness of treatment of patients with pulmonary tuberculosis by correcting autonomic dysfunction and reducing the volume of residual post-tuberculosis changes using dioxomethyltetrahydropyrimidine. Material and methods. The continuous prospective study included 70 healthy individuals (comparison group) and 77 tuberculosis patients (observation group) divided into 2 subgroups: 41 patients received only antituberculosis drugs, 36 received dioxomethyltetrahydropyrimidine in the adaptogen regimen as part of complex treatment. The presence and nature of autonomic dysfunction were assessed using heart rate variability study; the volume of residual lung changes formation during treatment and its relationship with autonomic dysfunction were analyzed. Results. The predominant influence of sympathetic nervous system with centralization of organism regulation more than 2 times more often than in healthy individuals was observed in tuberculosis patients. When assessing the state of the body regulatory systems during treatment and radiological outcomes of tuberculosis process, 77.3% of patients showed moderate functional tension and adaptation failure according to the activity index of regulatory systems, combined with the formation of pronounced residual tuberculous changes. Addition of dioxomethyltetrahydropyrimidine to antituberculosis therapy promoted the recovery of vegetative dysfunction. The correlation between restoration of autonomic function and reduction of formation of large residual tuberculous changes in lungs of tuberculosis patients was revealed (p < 0,001).