In vitro activity of itraconazole against yeast and mycelial fungi – pathogens of opportunistic mycoses in tuberculosis patients

The aim of the study was to determine the levels of sensitivity to itraconazole in 51 species of opportunistic fungi isolated from tuberculosis patients in the diagnosis of bronchopulmonary and disseminated mycoses. Materials and methods. The sensitivity levels to itraconazole of 902 clinical strains of yeast fungi from the genera Candida (14 species), Cryptococcus (3 species), Geotrichum (1 species) were determined, Hanseniaspora (1 species), Saccharomyces (1 species), Saprochaete (1 species), Rhodotorula (2 species), Trichosporon (1 species) and mycelial fungi from the genera Acremonium (1 species), Alternaria (1 species), Aspergillus (12 species), Aureobasidium (1 species), Cladosporium (1 species), Curvularia (1 species), Fusarium (3 species), Paecilomyces (2 species), Penicillium (2 species), Rhizopus (1 species), Trichoderma (2 species), isolated from tuberculosis patients with suspected bronchopulmonary and disseminated mycoses in the Moscow Research and Clinical Center of Tuberculosis Control in the period 2012–2024. Results. Testing revealed high activity of itraconazole against pathogens of candidiasis (except C. glabrata), cryptococcosis, aspergillosis (except A. ustus), pheohyphomycosis (genera Alternaria, Aureobasidium, Cladosporium, Curvularia), rare yeast mycoses (genera Geotasidium, Aureobasidium, Curvularia). ustus), pheohyphomycoses (genera Alternaria, Aureobasidium, Cladosporium, Curvularia), rare yeast mycoses (genera Geotrichum, Hanseniaspora, Saccharomyces, Saprochaete, Trichosporon), hyalohyphomycoses (genera Penicillium, Trichoderma). The activity of itraconazole was low against the pathogens Fusarium spp., Rhodotorulosis (Rhodotorula spp.), Zygomycosis (Rhizopus arrhizus) and variable against two hyalohyphomycetes Paecilomyces variotii and Acremonium strictum.