18F-fluorodeoxyglucose positron emission tomography-compute tomography parameters for predicting the prognosis and toxicity in children and young adults with large B-cell lymphoma receiving chimeric antigen receptor T-cell therapy
aaIPI and TMTV were independent risk factors for PFS, and ECOG score and TMTV had independent prognostic value for OS. Higher LDH and TMTV were associated with grade 2-4 CRS, and higher CRP was associated with more severe ICANS. Thus, integrating these metabolic parameters of <sup>18</sup>F-FDG PET/CT and clinical-laboratory indicators can be valuable for managing children and young adults with B-cell lymphoma who have received CAR T-cell therapy.
Authors
- Xilan Yao
- Shuang Yao (ORCID: https://orcid.org/0000-0003-3686-5404)
- Jigang Yang (ORCID: https://orcid.org/0000-0002-0538-7676)
- Hongrong Wang (ORCID: https://orcid.org/0000-0002-4980-1082)
- Weimin Wang (ORCID: https://orcid.org/0000-0002-9852-1589)
- Yang Xu (ORCID: https://orcid.org/0009-0002-9303-5001)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Beijing Friendship Hospital (CN)
- Beijing Fengtai Hospital (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2025-03-01
- DOI
- https://doi.org/10.21037/qims-24-1737
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05