Chrysosplenetin B suppresses the growth of human prostate cancer cells by inducing G1 cell cycle arrest
Our findings indicate that CspB effectively inhibits the proliferation of CRPC cells by reducing the activity of cell cycle proteins and cyclin-dependent kinase (CDK) complexes while upregulating the expression of P21 and P27 and inducing G1 phase cell cycle arrest. These results highlight the potential of CspB as a promising candidate for developing therapeutic agents aimed at targeting CRPC.
Authors
- Yanxia Song
- Tangcong Chen (ORCID: https://orcid.org/0000-0002-6839-6844)
- Yanjiao Feng
- Feng‐Zheng Chen
- Wei Liu (ORCID: https://orcid.org/0000-0001-7285-0520)
- Yiyuan Zhang (ORCID: https://orcid.org/0000-0001-9788-9958)
- Gang He (ORCID: https://orcid.org/0000-0001-5026-1493)
- Li Liang (ORCID: https://orcid.org/0009-0002-1362-4309)
- Jun Yan (ORCID: https://orcid.org/0000-0002-1303-1952)
Institutions
- Leshan Normal University (CN)
- Chengdu University (CN)
Publication Details
- Journal
- Bioimpacts
- Published
- 2025-03-02
- DOI
- https://doi.org/10.34172/bi.30688
- Citations
- 1
- Primary Topic
- Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.05