Propofol Induced Seizure Like Phenomenon During Modified Electroconvulsive Therapy

Background: Propofol is an intravenous anesthetic that is said to have anticonvulsant properties. This is a case report of the propofol-induced seizure-like phenomenon (SLP) during modified (MECT). Case Report: A 24-year-old female with severe depression without psychotic symptoms and borderline personality disorder underwent six sessions of MECT. During the earlier session of MECT using thiopentone as an anesthetic, a prolonged seizure occurred, indicating a low seizure threshold. Then, it was changed to propofol. When propofol was given as an induction agent, even before giving ECT, the patient developed seizure-like involuntary jerking movements. EEG and MRI were done after the fourth session and were found normal. Discussion: This case report highlights that even though propofol has anticonvulsant activity, few cases of SLP during procedures have been reported. Propofol-induced SLP during MECT is the first of its kind. Conflict of Interest: Rajmohan Velayudhan: The article was submitted on 30 July 2024. On 12 August, the author became editor-in-chief of the Journal. Adhering to COPE Guidelines, the previous editor and section editor processed and decided on the article. The current editor-in-chief was not involved in any processing or decision-making phase. The other authors have no conflict of interest.