Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients
Hospitalization in older adult patients elevates NOX2 blood levels, correlating with reduced muscle mass. Increased low-grade endotoxemia may trigger NOX2 activation, generating oxidative stress that accelerates muscle degeneration and can lead to sarcopenia.
Authors
- Pasquale Pignatelli (ORCID: https://orcid.org/0000-0002-2265-7455)
- Giovambattista Desideri (ORCID: https://orcid.org/0000-0002-0145-1271)
- Simona Bartimoccia (ORCID: https://orcid.org/0000-0002-6266-3059)
- Evaristo Ettorre
- Chiara Bagnato (ORCID: https://orcid.org/0009-0006-5952-5161)
- Pietro Enea Lazzerini (ORCID: https://orcid.org/0000-0001-6721-1214)
- Elena Mereu (ORCID: https://orcid.org/0009-0003-0198-7062)
- Alessandra D’Amico (ORCID: https://orcid.org/0000-0002-5571-4583)
- Arianna Magna
- Roberto Carnevale (ORCID: https://orcid.org/0000-0002-6216-9595)
- Francesco Violi (ORCID: https://orcid.org/0000-0002-6610-7068)
- Lorenzo Loffredo (ORCID: https://orcid.org/0000-0002-6542-6235)
- Roberta Marti
- Sciaila Bernardini
Institutions
- University of Siena (IT)
- Policlinico Umberto I (IT)
- Istituto Neurologico Mediterraneo (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Antioxidants
- Published
- 2025-03-01
- DOI
- https://doi.org/10.3390/antiox14030304
- Citations
- 5
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 5.82