Progesterone and progesterone receptors in breast cancer: past, present, and future
The history of progesterone and progesterone receptors (PR) in breast cancer is as great, as controversial. In this review, we summarize the early history of PR research in breast cancer, debunk the myth that progesterone causes cancer, discuss recent discoveries in PR regulating cellular heterogeneity, attempt to reconcile theories that PR play “good” and “bad” role in tumorigenesis, and discuss new directions that may help elucidate the role of this puzzling hormone and its receptors.
Authors
- M. V. Rodionova (ORCID: https://orcid.org/0000-0002-0658-1454)
- O. V. Burmenskaya (ORCID: https://orcid.org/0000-0003-2842-3980)
- В. В. Кометова (ORCID: https://orcid.org/0000-0001-9666-6875)
- A. A. Smetnik (ORCID: https://orcid.org/0000-0002-0627-3902)
- Л.М. Михалева (ORCID: https://orcid.org/0000-0003-2052-914X)
- Yu. V. Bikeev
- I. V. Kolyadina (ORCID: https://orcid.org/0000-0002-1124-6802)
- L. А. Ashrafyan (ORCID: https://orcid.org/0000-0001-6396-4948)
- В. В. Родионов (ORCID: https://orcid.org/0000-0003-0096-7126)
- K. V. Bozhenko (ORCID: https://orcid.org/0000-0001-8351-8152)
Institutions
- Russian Medical Academy of Continuous Professional Education (RU)
- Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology (RU)
- Ministry of Health of the Russian Federation (RU)
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation (RU)
- Research Institute of Human Morphology (RU)
Publication Details
- Journal
- Tumors of female reproductive system
- Published
- 2024-12-03
- DOI
- https://doi.org/10.17650/1994-4098-2024-20-4-70-80
- Citations
- 1
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.55