Manifestations of salivary gland pathology in patients after radioiodine therapy for thyroid diseases

Radioiodine therapy is performed for highly differentiated papillary and follicular prostate cancer. The manifestation of the side effect of radioiodine therapy on the salivary glands leads to structural and functional changes in healthy organs. Background. The presence of persistent symptoms and manifestations of sialoadenitis underscores the need to find preventive measures for radio-induced sialoadenitis. The combination of a history of thyroid cancer and concomitant complications of salivary gland diseases requires dynamic monitoring and determination of the quality of life of this group of patients after RT. Material and methods. As a result of the examination of 70 patients at different times after radiation therapy, various combinations of damage to one or more salivary glands were identified and described in this article during clinical and X-ray examination. According to the sociological survey and laboratory diagnosis of thyroid hormones, the assessment of the quality of life of these patients was carried out. Statistical processing of the obtained results. Results. It was revealed that the development of post-radiation sialoadenitis in the early and delayed periods after radioiodine therapy is characterized by a variety of clinical and structural manifestations. The presence of thyroid cancer and pronounced radio-induced manifestations from the salivary glands significantly affect the quality of life of patients. Conclusions. The progression of salivary gland disease does not depend on the administered total therapeutic dose of sodium iodide, gender, age. The undesirable effects of radioiodine therapy on the salivary glands against the background of thyroid disease negatively affect the quality of life.