Prenatal Renal Vein Thrombosis

<b>Background:</b> The neonatal period has a number of characteristics leading to an increased risk of severe and, in many cases, life-threatening complications. Renal venous thrombosis is one of them. It accounts for 16-20% of all thromboembolisms in the neonatal period. Due to the delicate balance in coagulation status in the first days after birth, conditions such as infections, hypoxia, hypotension, and dehydration can lead to the occurrence of this complication. The incidence of renal thrombosis is 2.2/100,000 live births, with cases of intrauterine renal thrombosis being even rarer (7% of cases). The diagnosis of the disease is usually performed using ultrasound examination and Doppler sonography, although contrast angiography is the gold standard for diagnosing these conditions. <b>Case presentation:</b> We present a clinical case of a male child with manifestations of diabetic fetopathy and prenatally occurring venous thrombosis of the right kidney, confirmed by ultrasound 2 h after birth. <b>Results:</b> The occurrence and evolution of venous thrombosis was monitored through a series of ultrasound examinations. Despite the restoration of renal blood flow after the initiation of therapy, long-term follow-up at 6 and 12 months revealed the onset of renal atrophy. <b>Conclusions:</b> Prenatal renal vein thrombosis is a rare but severe pathology for the newborns. Ultrasound examination is the method of first choice in cases of suspected renal vein thrombosis, as well as for renal blood flow restoration and for the monitoring of the fate of the affected kidney.

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Journal
Children
Published
2025-02-28
DOI
https://doi.org/10.3390/children12030319
Primary Topic
Blood Coagulation and Thrombosis Mechanisms
Type
article
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article

Prenatal Renal Vein Thrombosis

Ivanka Nikolova Paskaleva, Stoyan Markov, Petya Petkova Markova, Mariya Neshterova
Children
Blood Coagulation and Thrombosis Mechanisms
article

Prenatal Renal Vein Thrombosis

Ivanka Nikolova Paskaleva, Stoyan Markov, Petya Petkova Markova, Mariya Neshterova
article en

Abstract

<b>Background:</b> The neonatal period has a number of characteristics leading to an increased risk of severe and, in many cases, life-threatening complications. Renal venous thrombosis is one of them. It accounts for 16-20% of all thromboembolisms in the neonatal period. Due to the delicate balance in coagulation status in the first days after birth, conditions such as infections, hypoxia, hypotension, and dehydration can lead to the occurrence of this complication. The incidence of renal thrombosis is 2.2/100,000 live births, with cases of intrauterine renal thrombosis being even rarer (7% of cases). The diagnosis of the disease is usually performed using ultrasound examination and Doppler sonography, although contrast angiography is the gold standard for diagnosing these conditions. <b>Case presentation:</b> We present a clinical case of a male child with manifestations of diabetic fetopathy and prenatally occurring venous thrombosis of the right kidney, confirmed by ultrasound 2 h after birth. <b>Results:</b> The occurrence and evolution of venous thrombosis was monitored through a series of ultrasound examinations. Despite the restoration of renal blood flow after the initiation of therapy, long-term follow-up at 6 and 12 months revealed the onset of renal atrophy. <b>Conclusions:</b> Prenatal renal vein thrombosis is a rare but severe pathology for the newborns. Ultrasound examination is the method of first choice in cases of suspected renal vein thrombosis, as well as for renal blood flow restoration and for the monitoring of the fate of the affected kidney.

ChildrenVol. 12(3)
Plovdiv University (BG), Medical University Plovdiv (BG)
Openalex Percentile: Top 94%
Blood Coagulation and Thrombosis Mechanisms
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