Functional validation to explore the protective role of miR-223 in Staphylococcus aureus-induced bovine mastitis
In summary, miR-223 has an inhibitory effect on S. aureus-induced cell apoptosis and necrosis by regulating PTPRF, DCTN1, and DPP9. These genes were significantly enriched in QTL regions associated with bovine mastitis resistance, underscoring their relevance in genetic regulation of disease resilience. Our findings provide critical genetic markers for enhancing mastitis resistance, particularly S. aureus-induced mastitis, through selective breeding. This work offers valuable insights for developing cattle with improved resistance to mastitis via targeted genetic selection.
Authors
- Dage Liu (ORCID: https://orcid.org/0000-0002-5412-2535)
- Siyuan Mi (ORCID: https://orcid.org/0000-0003-4950-689X)
- Jiuzhou Song (ORCID: https://orcid.org/0000-0002-6973-5959)
- David E. MacHugh (ORCID: https://orcid.org/0000-0002-8112-4704)
- Ying Yu (ORCID: https://orcid.org/0000-0003-4772-413X)
- Gerile Dari
- Siqian Chen (ORCID: https://orcid.org/0000-0001-8358-8732)
Institutions
- University College Dublin (IE)
- Beijing University of Agriculture (CN)
- China Agricultural University (CN)
- University of Maryland, College Park (US)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s40104-025-01152-6
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75