A novel synthetic approach for the piperazynyl pyrimidine intermediate: focus on the cost cutting of buspirone drug at commercial level
The developed synthesis method for 2-(piperazin-1-yl) pyrimidine was both cost-effective and efficient, significantly enhancing the yield and purity. This method is highly suitable for large-scale pharmaceutical production, aligning with industry goals of improved process efficiency, cost reduction and environmental sustainability.
Authors
- Divya Bajpai Tripathy (ORCID: https://orcid.org/0000-0002-2404-5460)
- A. NAYAK
- Dhananjay S. Pendharkar
- Vijay Kumar Sharma (ORCID: https://orcid.org/0000-0002-2028-5715)
- Gaurav Sharma (ORCID: https://orcid.org/0000-0001-9735-9519)
Institutions
- Galgotias University (IN)
- Bioscience (China) (CN)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1080/03639045.2025.2473505
- Primary Topic
- Chemistry and Chemical Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00