Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal Adenocarcinomas
We identified previously reported pathways involved in PNI, including Axonal Guidance and ROBO-SLIT Signaling. Spatial transcriptomics highlighted the role of PNI foci in influencing the immune landscape of the TME and similarities between PNI and nerve injury response. This study revealed that endocannabinoid and polyamine metabolism may contribute to PNI, cancer growth and cancer pain. Key members of these pathways can be targeted, offering potential novel research avenues for exploring new cancer treatment and/or pain management options in PDAC.
Authors
- Vanessa Lakis (ORCID: https://orcid.org/0000-0001-5025-8120)
- Nicholas P. West (ORCID: https://orcid.org/0000-0002-5482-4182)
- Ann‐Marie Patch (ORCID: https://orcid.org/0000-0001-6121-4019)
- Anthony James Gill (ORCID: https://orcid.org/0000-0002-9447-1967)
- Tam Nguyen (ORCID: https://orcid.org/0000-0002-9833-4062)
- Glen M. Boyle (ORCID: https://orcid.org/0000-0002-1385-529X)
- Noni Chan (ORCID: https://orcid.org/0000-0002-6031-3944)
- Andrew Masel (ORCID: https://orcid.org/0000-0001-6314-0471)
- Kátia Nones (ORCID: https://orcid.org/0000-0003-1925-5196)
- Crystal Chang (ORCID: https://orcid.org/0000-0002-0647-7040)
- Nicola Blackburn
- Ruth J. Lyons
Institutions
- Griffith University (AU)
- The University of Sydney (AU)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Royal North Shore Hospital (AU)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-01
- DOI
- https://doi.org/10.3390/cancers17050852
- Citations
- 9
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 9.41